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Journal of Dairy Science Vol. 76 No. 6 1550-1557
© 1993 by American Dairy Science Association ®
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Galactopoietic Effects of Recombinant Somatotropin and Growth Hormone-Releasing Factor in Dairy Cows

G. E. Dahl 1, L. T. Chapin 1, W. M. Moseley 1, and H. A. Tucker 1

1 Department of Animal Science, Animal Reproduction Laboratory, Michigan State University, East Lansing 48824 and The Upjohn Company, 7921-25-4, Performance Enhancement Research, Kalamazoo, MI 49001

Eight Holsteins per group received 12 mg/d of recombinant growth hormone-releasing factor or 29 mg/d of recombinant bST or served as untreated controls for 60 d. Milk yield and composition were measured for 10 d before infusion, during infusion (d 0 to 59), and for 20 d after infusion ended. Compared with controls, bST and growth hormone-releasing factor increased SCM during infusion. The SCM yield of cows treated with growth hormone-releasing factor was greater than that of bST-treated cows during the final 20 d of infusion. Relative to controls, bST and growth hormone-releasing factor increased serum concentrations of somatotropin and IGF-I during infusion. Concentrations of somatotropin and IGF-I in serum of bST-and growth hormone-releasing factor-treated cows did not differ during infusion. In summary, growth hormone-releasing factor increased SCM yield more than bST, despite similar serum concentrations of somatotropin and IGF-I. Thus, the galactopoietic action of growth hormone-releasing factor was not explained solely by elevation of total radioimmunoassayable somatotropin and IGF-I in serum.

Key Words: growth hormone-releasing factor • somatotropin • milk yield

Submitted on August 3, 1992
Accepted on February 11, 1993




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J. Yang, B. Zhao, V. E. Baracos, and J. J. Kennelly
Effects of Bovine Somatotropin on {beta}-Casein mRNA Levels in Mammary Tissue of Lactating Cows
J Dairy Sci, August 1, 2005; 88(8): 2806 - 2812.
[Abstract] [Full Text] [PDF]


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