| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Animal Sciences, University of Vermont, Burlington 05405
Epidermal growth factor, transforming growth factor-
and transforming growth factor-ß1 are potent effectors of mammary growth that work in concert with endocrine hormones, such as estrogen, progesterone, corticosteroids, and prolactin. Estrogen and progesterone stimulate production of epidermal growth factor or transforming growth factor- to stimulate mammary growth. Epidermal growth factor and prolactin synergize in whole organ culture to cause lobulo-alveolar development and to alter the profile of synthesized milk proteins. Transforming growth factor-ß1 inhibits mammary development of prepubertal mice. However, once the gland is committed to differentiation, transforming growth factor-ß1 no longer affects mammary morphogenesis. The role of transforming growth factor-ß1 in milk protein synthesis is unknown.
Transforming growth factor- and -ß1 mRNA have both been identified in the mammary gland of cows. The gland has epidermal growth factor receptors, and epidermal growth factor or transforming growth factor- can stimulate proliferation of mammary epithelial cells in vitro. The role of transforming growth factor-ß1 in bovine mammary tissue has not been studied. An understanding of the role of epidermal growth factor, the transforming growth factors, and their interactions with endocrine hormones will lead to a more complete understanding of how mammary development and lactation are regulated.
Key Words: mammary • epidermal growth factor • transforming growth factor- • transforming growth factor-ßbeta;
Submitted on June 22, 1992
Accepted on December 21, 1992
This article has been cited by other articles:
|
|
 |
|
  R. M. Akers Major advances associated with hormone and growth factor regulation of mammary growth and lactation in dairy cows. J Dairy Sci, April 1, 2006; 89(4): 1222 - 1234. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Tomlinson, C. H. Mulling, and T. M. Fakler Invited Review: Formation of Keratins in the Bovine Claw: Roles of Hormones, Minerals, and Vitamins in Functional Claw Integrity J Dairy Sci, April 1, 2004; 87(4): 797 - 809. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Musters, K. Coughlan, T. McFadden, R. Maple, T. Mulvey, and K. Plaut Exogenous TGF-{beta}1 Promotes Stromal Development in the Heifer Mammary Gland J Dairy Sci, April 1, 2004; 87(4): 896 - 904. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Song and T. Oka Regulation of type II deiodinase expression by EGF and glucocorticoid in HC11 mouse mammary epithelium Am J Physiol Endocrinol Metab, June 1, 2003; 284(6): E1119 - E1124. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. M. Casey, A. Boecker, J.-F. Chiu, and K. Plaut Glucocorticoids Maintain the Extracellular Matrix of Differentiated Mammary Tissue During Explant and Whole Organ Culture Experimental Biology and Medicine, June 1, 2000; 224(2): 76 - 86. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
