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Journal of Dairy Science Vol. 76 No. 6 1514-1519
© 1993 by American Dairy Science Association ®
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B-Cell Mitogen Produced by Slime-Forming, Encapsulated Lactococcus lactis ssp. cremoris Isolated from Ropy Sour Milk, Viili

Haruki Kitazawa 1, Takahiro Yamaguchi 1, Makoto Miura 1, Tadao Saito 1, and Takatoshi Itoh 1

1 Department of Animal Science, Faculty of Agriculture, Tohoku University, Aobaku, Sendai 981, Japan

A substance, active as a B-cell mitogen, was isolated from the slime products produced by Lactococcus lactis ssp. cremoris KVS20. The mitogenic substance was prepared by anion-exchange chromatography and gel filtration chromatography and then purified by proteinase digestion and HPLC. Chemical analysis determined that the mitogenic substance was a phosphopolysaccharide and consisted of rhamnose, glucose, galactose, and phosphorus. The activity of the mitogenic substance was higher than that of the slime products. The optimal concentration for the activity was approximately 120 µg/ml. The mitogenic substance also had substantial mitogenic activity to spleen cells from C3H/HeJ mice, which are resistant to lipopolysaccharide. The findings indicated that a B-cell mitogen different from lipopolysaccharide is produced from L. lactis ssp. cremoris KVS20.

Key Words: Lactococcus lactis ssp. cremoris • slime product • phosphopolysaccharide • B-cell mitogen

Submitted on October 26, 1992
Accepted on January 8, 1993




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Copyright © 1993 by the American Dairy Science Association ®.