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Journal of Dairy Science Vol. 76 No. 11 3437-3444
© 1993 by American Dairy Science Association ®
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Efficacy of Intramammary Antibiotic Therapy for Treatment of Clinical Mastitis Caused by Environmental Pathogens

W. M. Guterbock 1, A. L. Van Eenennaam 1, R. J. Anderson 1, I. A. Gardner 1, J. S. Cullor 1, and C. A. Holmberg 1

1 School of Veterinary Medicine, University of California, Davis 95616

For three California dairy herds with bulk tank SCC <200,000/ml, twice daily milking, and no mastitis vaccine, 254 quarters with mild clinical mastitis were randomly assigned to three groups. Group A (n = 74) was treated with 62.5 mg of intramammary amoxicillin every 12 h for three milkings. Group C (n = 75) was treated with 200 mg of intramammary cephapirin every 12 h for two milkings. Group O (n = 105) was treated with 100 units of intramuscular oxytocin every 12 h for two or three milkings. Aseptic pretreatment quarter samples revealed 94 (37%) coliforms, 65 (26%) environmental streptococci, 34 (13%) other bacteria, and 61 (24%) with no isolate on bovine blood agar plates. Contagious pathogens were not isolated. Clinical cure (return of quarter and milk to normal) and bacterial cure (absence of primary pathogen isolated pretreatment) were assessed at milking 8 and d 20 after initial treatment. No difference existed in clinical (67.6, 67.7, or 66.7%) or bacterial (43.9, 55.0 or 49.1%) cure rate among groups. Clinical cure rates did not differ when quarters were grouped by etiology, but clinical cure rates for quarters with pathogens other than streptococci or coliforms were lower in group O.

Key Words: mastitis • treatment • oxytocin • intramammary antibiotics

Submitted on March 15, 1993
Accepted on June 10, 1993




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