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Journal of Dairy Science Vol. 75 No. 5 1253-1256
© 1992 by American Dairy Science Association ®
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1alpha-Hydroxycholecalciferol for the Treatment of the Downer Cow Syndrome

J.-P. Barlet 1 and M.-J. Davicco 1

1 Métabolisme Minéral, Institut National de la Recherche Agronomique, Theix 63122 St-Genès-Champanelle, France

Seventeen Holstein cows that showed clinical and biochemical symptoms (hypocalcemia and hypophosphatemia) of parturient hypocalcemia within 48 h postcalving and did not respond to Ca therapy were divided into two groups. Eight cows received a second intravenous Ca infusion 24 h after the first one. This treatment increased plasma Ca concentration but had no significant effect on phosphatemia, and the cows remained unable to rise and stand during 48 h following this second Ca infusion. The 9 other cows received 1alpha-hydroxycholecalciferol (1µg/kg of BW, half the dose intravenously, the other half intramuscularly). 1alpha-Hydroxycholecalciferol induced a significant increase in plasma P concentration and recovery of all the 9 cows within 12 h after this treatment.

Key Words: phosphorus • calcium • paresis • cow

Submitted on October 18, 1991
Accepted on December 18, 1991




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