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Journal of Dairy Science Vol. 74 No. 8 2788-2800
© 1991 by American Dairy Science Association ®
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Control of Growth and Differentiation of the Mammary Gland by Growth Factors

Takami Oka 1, Masami Yoshimura 1, Sergio Lavandero 1, Katsuya Wada 1, and Yoshito Ohba 1

1 Section on Cell Growth and Differentiation, Laboratory of Molecular and Cellular Biology, National Institute of Diabetes, Digestive and Kidney Diseases, Building 8, Room 304, National Institutes of Health, Bethesda, Maryland 20892

Mammary gland development is a complex process regulated by various steroid and polypeptide hormones. Although the systemic importance of hormones, such as estrogen, progesterone, prolactin, and growth hormone, in the growth of the mammary gland has been well documented, these hormones are virtually incapable of stimulating mammary cell growth in vitro. Thus, the growth stimuli for mammary cells requires clarification. In recent years, a number of growth factors have been discovered; this has prompted interest in examining possible involvement of these biologically active agents in the process of mammary gland development. Results presented herein indicate that several growth factors including epidermal growth factor, transforming growth factor alpha and ß, basic fibroblast growth factor, insulin-like growth factor-I, and mesenchyme-derived growth factor participate in the regulation of mammary cell growth and differentiation.

Key Words: growth factors • mammary development

Submitted on August 31, 1990
Accepted on April 17, 1991




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Copyright © 1991 by the American Dairy Science Association ®.