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Journal of Dairy Science Vol. 74 No. 2 695-705
© 1991 by American Dairy Science Association ®
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Adenosine and the Control of Adrenergic Regulation of Adipose Tissue Lipolysis During Lactation

Richard G. Vernon 1, Eric Finley 1, and Paul W. Watt 1

1 Department of Biochemistry and Molecular Biology, Hannah Research Institute, Ayr KA6 5HL, Scotland, UK

Adenosine is a locally active factor that is produced intracellularly and extracellularly in adipose tissue. Adenosine binds to receptors in the plasma membrane of adipocytes; this activates a guanine triphosphate binding protein that inhibits adenylate cyclase activity and, hence, lipolysis. Lactation results in an enhanced responsiveness of adipocytes to ß-agonists, which stimulate lipolysis, and, paradoxically, to adenosine, which inhibits lipolysis. These adaptations are partly due to increases in ligand binding and to changes in postreceptor components of the signal transduction systems. Somatotropin is implicated in the chronic adaptations of the ß-adrenergic system, whereas insulin, somatotropin, glucocorticoids, and at least one unidentified factor have a role in the chronic control of the adenosine system of adipocytes.

Key Words: adenosine • adipose tissue • lipolysis

Submitted on September 7, 1989
Accepted on January 29, 1990




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J. M. Sumner and J. P. McNamara
Expression of Lipolytic Genes in the Adipose Tissue of Pregnant and Lactating Holstein Dairy Cattle
J Dairy Sci, November 1, 2007; 90(11): 5237 - 5246.
[Abstract] [Full Text] [PDF]


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Copyright © 1991 by the American Dairy Science Association ®.