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Journal of Dairy Science Vol. 73 No. 3 627-632
© 1990 by American Dairy Science Association ®
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Physiological Responses to Intramammary or Intravenous Treatment with Endotoxin in Lactating Dairy Cows

J. A. Jackson 1, D. E. Shuster 1, W. J. Silvia 1, and R. J. Harmon 1

1 Department of Animal Sciences, University of Kentucky, Lexington 40546-0215

Twenty-one, middle to late lactation Holstein cows were assigned to one of three treatments in a completely randomized design to examine physiological changes associated with intramammary or intravenous administration of Escherichia coli endotoxin. Treatments were 1) Hank's balanced salt solution infusion in two contralateral quarters (control), 2) E. coli endotoxin infusion in two contralateral quarters, and 3) intravenous infusion of E. coli endotoxin. Blood was sampled and rectal temperature was measured at 30-min intervals. Endotoxin treatment was at 0900 h and sampling continued until 1700 h. Serum prolactin, cortisol, and 13,14-dihydro-15-keto-prostaglandin F2alpha were measured.

A pyretic response was observed in intravenous and intramammary treatment groups after endotoxin treatment. Response peak was higher (41.1 vs. 40.3°C) and occurred later (6 vs. 4.5 h posttreatment) in the intramammary than the intravenous treatment group. Significant prolaclin peaks were observed also in intravenous and intramammary endotoxin treatment groups. Prolacrin peaked higher (288 vs. 112 ng/ml) and occurred sooner (1 vs. 4 h posttreatment) in the intravenous than in the intramammary treatment group. Cortisol followed a trend similar to prolaclin. Cortisol peaked higher (100 vs. 82 ng/ml) and sooner (2.5 vs. 4.5 h posttreatment) in the intravenous than in the intramammary treatment group. Concentrations of 13,14-dihydro-15-keto-prostaglandin F2alpha increased rapidly post-treatment in the intravenous group only.

Key Words: endotoxin • prostaglandin • control

Submitted on May 11, 1989
Accepted on September 21, 1989




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