JDS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Journal of Dairy Science Vol. 73 No. 12 3439-3448
© 1990 by American Dairy Science Association ®
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Newton, G. R.
Right arrow Articles by Voirol, M.-J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Newton, G. R.
Right arrow Articles by Voirol, M.-J.

Effect of Bovine Interferon on Acute Changes in Body Temperature and Serum Progesterone Concentration in Heifers

G. R. Newton 1, S. Martinod 1, P. J. Hansen 1, W. W. Thatcher 1, B. Siegenthaler 1, C. Gerber 1, and M.-J. Voirol 1

1 Dairy Science Department, University of Florida, Gainesville 32611 and CIBA-GEIGY, S.A., Centre de Recherches Agricoles, CH-1566 St. Aubin, Switzerland

Bovine interferon-alphaI1 has extensive sequence and functional homology with the antiluteolytic protein, bovine trophoblast protein-1. Because of the possible use of interferon-alphaI1 as a drug that supplements embryonic secretion of bovine trophoblast protein-1, interferon-alphaI1 was tested for other biological actions that might affect its usefulness as a fertility-enhancing treatment. Experiments were performed to evaluate whether interferon-alphaI1 causes hyperthermia and an acute depression in circulating concentrations of progesterone. In four experiments, intramuscular administration of interferon-alphaI1 (range 1.25 to 20 mg) caused hyperthermia; average peak body temperatures of 40 to 40.4°C occurred 2.5 to 6 h after injection. Temperatures returned to baseline 12 to 16 h later. The rise in rectal temperature could be reduced, but not totally alleviated, with concomitant administration of an inhibitor of prostaglandin synthesis. The maximal hyperthermic response was similar when interferon-alphaI1 was delivered via osmotic minipumps or through a series of intramuscular injections. The hyperthermic response decreased with repeated daily exposure to interferon-alphaI1. The increase in rectal temperatures was associated temporally with a decrease in serum progesterone. Effects of interferon-alphaI1 on body temperature and circulating progesterone could possibly limit its effectiveness in enhancing fertility.

Key Words: interferon-alpha • hyperthermia • progesterone

Submitted on December 14, 1989
Accepted on August 1, 1990




This article has been cited by other articles:


Home page
 J ANIM SCIHome page
M. L. Merrill, R. P. Ansotegui, P. D. Burns, M. D. MacNeil, and T. W. Geary
Effects of flunixin meglumine and transportation on establishment of pregnancy in beef cows
J Anim Sci, June 1, 2007; 85(6): 1547 - 1554.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
T. E. Spencer, A. G. Stagg, T. L. Ott, G. A. Johnson, W. S. Ramsey, and F. W. Bazer
Differential Effects of Intrauterine and Subcutaneous Administration of Recombinant Ovine Interferon Tau on the Endometrium of Cyclic Ewes
Biol Reprod, August 1, 1999; 61(2): 464 - 470.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1990 by the American Dairy Science Association ®.