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Metabolic Effects of Intraruminal Administration of 1,3-Butanediol or Tributyrin in Lactating Goats¹

Nutritional Physiology Group, Department of Animal Science, Iowa State University, Ames 50011

ABSTRACT

Acute effects of dietary 1,3-butanediol and tributyrin on concentrations of glucose, ß-hydroxybutyrate, and insulin in plasma were compared in lactating goats. In Experiment 1, glucose was decreased by intraruminai administration of 75 or 150 g of 1,3-butanediol or by 84 or 168 g of tributyrin. Tributyrin caused transient hyperglycemia immediately after administration. ß-Hydroxybutyrate was increased in a dose-dependent manner by tributyrin and increased independently of dose by 1,3-butanediol. Tributyrin, but not 1,3-butanediol, caused large increases of insulin in plasma. In Experiment 2, 75 g of 1,3-butanediol or 84 g of tributyrin administered intraruminally decreased glucose, whereas 73 g of butyric acid (pH 5.6) increased glucose compared with water or 25.6 g of glycerol. All treatments produced transient hyperglycemia immediately after administration. Tributyrin, butyric acid, or 1,3-butanediol greatly increased ß-hydroxybutyrate compared with administration of water or glycerol. Concentrations of ß-hydroxybutyrate in both experiments increased more slowly for 1,3-butanediol than for tributyrin. Both 1,3-butanediol and tributyrin decreased glucose and increased ß-hydroxybutyrate. Because 1,3-butanediol does not stimulate increases of insulin in plasma, it may be more desirable than tributyrin for inducing metabolic changes characteristic of lactation ketosis.

¹ Journal Paper Number J-13277 of the Iowa Agriculture and Home Economics Experiment Station, Ames: Projects Number 2578 and 2736. This paper is based upon data in a thesis submitted to Iowa State University by Y. Zhang in partial fulfillment of requirements for the M. S. degree.

² Department of Animal Sciences, University of Illinois, Urbana.

³ Dairy Science Department, Louisiana State University, Baton Rouge.

⁴ Department of Animal Sciences, University of Kentucky, Lexington.

⁵ Reprint requests.