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Plasma Tocopherol in Sheep and Cattle After Ingesting Free or Acetylated Tocopherol^1,2,

Animal Science Department, University of Florida, Gainesville 32611-0691

ABSTRACT

Two trials were carried out to evaluate the bioavailability of dl--tocopherol and dl--tocopherol acetate administered to sheep and cattle in a single oral dose. In the first trial, two groups of five sheep were used. They received 100 mg/kg body weight of either dl--tocopherol or its acetylated form. The blood plasma -tocopherol tolerance curve area was higher in the dl--tocopherol group than in its ester form. The time to reach maximum plasma -tocopherol concentration was less in the dl--tocopherol group than in its ester form. In a second trial, four heifers received the two forms (50 mg/kg body weight) in rotation after an appropriate washing period between the two dosings. Again, plasma tolerance curve area was greater in the cattle following administration of dl--tocopherol than its acetylated form.

¹ Florida Agricultural Experiment Station Journal Series Number 9323.

² This research was supported, in part, by the US Department of Agriculture under CSRS special grant Number 86-CRSR-2-2843 managed by the Caribbean Advisory Group (CBAG), and Hoffmann-La Roche Inc., Nutley, NJ.

³ Present address: Estación Experimental Agropecuaria - Colonia Benítez, Casilla de Correo 114, 3500 Resistencia, Chaco, Argentina.