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Effect of Indomethacin Administration on Glucose Homeostasis and Pancreatic Hormones in Lactating Goats^1,2,

Division of Animal and Veterinary Sciences, West Virginia University, Morgantown 26506-6108

ABSTRACT

To determine glucogenic and hormonal responses in ruminants to indomethacin, a prostaglandin synthetase inhibitor, four lactating Toggenburg goats were used in a crossover design. Fifteen milligrams of indomethacin or 3 ml of saline were injected subcutaneously twice daily with propionate infused intrajugularly at a rate of 2 mM/min for 75 min as a challenge. Plasma glucose concentrations were increased by indomethacin injections. Plasma concentrations of insulin, glucagon, and 6-keto-prostaglandin F₁ were not affected by indomethacin injections. Propionate infusion elevated plasma glucose, insulin, and glucagon concentrations. A decreased insulin release in response to propionate challenge was observed with indomethacin injections.

¹ Published with the approval of the Director of the West Virginia Agricultural and Forestry Experiment Station as Scientific Paper Number 2086.

² The authors wish to acknowledge the assistance of D. Vincent for 6-keto-prostaglandin-F₁ analysis and E. Townsend for statistical help.

³ To whom reprint requests should be sent.