HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lohuis, J.A.C.M. Articles by Brand, A. Search for Related Content PubMed PubMed Citation Articles by Lohuis, J.A.C.M. Articles by Brand, A.

Effect of Dexamethasone on Experimental Escherichia coli Mastitis in the Cow

College of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands

² Reprint requests.

ABSTRACT

The effect of intramuscular administration of dexamethasone on milk production and on several clinical and hematologic indicators in cows with experimental Escherichia coli mastitis was studied. Two groups of three cows each were intramammarily inoculated with 20 x 10⁵ cfu E. coliO101 K99 F41 in rear quarters. Immediately after inoculation one groups received 30 mg dexamethasone intramuscularly, whereas the other group was injected similarly with pyrogen-free saline. Fourteen days later milk production losses were markedly less in the dexamethasone-treated group. Dexamethasone treatment reduced local clinical signs of inflammation, significantly increased rectal temperatures, and diminished inhibition of rumen amplitude during the acute phase of infection. Moreover, cows treated with dexamethasone showed diminished neutropenia, more pronounced hypozincemia, and delayed onset in the decrease in plasma iron concentrations. Possible mechanisms by which these changes are accomplished are discussed.

¹ Department of Herd Health and Reproduction, Yalelaan 7, De Uithof, 3508 TD, Utrecht.

³ Department of Veterinary Pharmacology, Pharmacy, and Toxicology. Biltstraat 172, Utrecht.

This article has been cited by other articles:

				J. R. Wenz, G. M. Barrington, F. B. Garry, R. P. Ellis, and R. J. Magnuson Escherichia coli Isolates' Serotypes, Genotypes, and Virulence Genes and Clinical Coliform Mastitis Severity. J Dairy Sci, September 1, 2006; 89(9): 3408 - 3412. [Abstract] [Full Text] [PDF]