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Journal of Dairy Science Vol. 70 No. 8 1671-1675
© 1987 by American Dairy Science Association ®
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Use of 1{alpha}-Hydroxyvitamin D3 in the Prevention of Bovine Parturient Paresis. IX. Early and Late Effects of a Single Injection1

M. Sachs2, R. Perlman and A. Bar3

Institute of Animal Science, Agricultural Research Organization, The Vocani Center, Bet Dagan, Israel

3 To whom reprint requests should be sent

ABSTRACT

Israeli Friesian cows in the third or later lactation were injected intramuscularly (serratus muscle of the neck) with 1{alpha}-hydroxyvitamin D3 in propylene glycol in order to compare the short-term and long-term effects of the drug. Following injection of 700 µg 1{alpha}-hydroxyvitamin D3, the D-derivative appeared in the plasma after 12 h and reached a peak 24 h after injection. Plasma 1,25-dihydroxyvitamin D increased as early as 6 h and peaked at 24 h. Plasma calcium increased after 6 h and peaked 4 to 5 d after the injection. The administration of a single dose of 350 µg 1{alpha}-hydroxyvitamin D3 at 7 to 8 d before calving did not prevent periparturient hypocalcaemia observed in the uninjected control cows. A single injection of 700 µg 1{alpha}-hydroxyvitamin D3 7 to 8 d before parturition prevented hypocalcemia at calving. There were no significant differences in plasma calcium 4 to 21 d after calving between the injected and control cows nor were there any cases of delayed postparturient hypocalcemia or milk fever. Results suggest that 700 µg 1{alpha}-hydroxyvitamin D3 prolonged the calcemic effect of the drug and prevented hypocalcemia at parturition, even if administered 6 to 8 d before calving.

FOOTNOTES

1 Contribution from the Agricultural Research Organization, The Volcani Center, Bet Dagan, Israel. Number 1788-E, 1986 series. This research was supported by grants from the US-Israel Binational Agricultural Research and Development Fund (BARD 352-81) and by Teva Ltd., Israel.

2 Haklait, Veterinary Clinical Services, Netanya, Israel.






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Copyright © 1987 by the American Dairy Science Association ®.