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Journal of Dairy Science Vol. 69 No. 9 2416-2423
© 1986 by American Dairy Science Association ®
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Excretion of Deoxynivalenol and Its Metabolite in Milk, Urine, and Feces of Lactating Dairy Cows

L.-M. Côté1, A. M. Dahlem, T. Yoshizawa2, S. P. Swanson and W. B. Buck

Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois, Urbana 61801

ABSTRACT

Corn contaminated with deoxynivalenol was added to the diets of three dairy cows for 5 d and milk, urine, and feces were collected prior to, during, and 3 d following feeding of the diets. Dietary concentrations of deoxynivalenol averaged 66 mg/kg. Following exposure to deoxynivalenol, unconjugated deepoxydeoxynivalenol, a metabolite of deoxynivalenol, was present in milk at concentrations up to 26 ng/ml. Deoxynivalenol was not detected in the milk. Approximately 20% of the deoxynivalenol fed was recovered in the urine and feces in the unconjugated forms as deepoxydeoxynivalenol (96%) and deoxynivalenol (4%). After incubating urine with ß-glucuronidase, the concentration of unconjugated deepoxydeoxynivalenol increased by 7 to 15-fold whereas unconjugated deoxynivalenol increased 1.6 to 3-fold.

Detectable concentrations of unconjugated deepoxydeoxynivalenol were found in urine and feces up to 72 h after the last oral exposure. Thus, urine and feces are the diagnostic specimens of choice for the determination of deoxynivalenol exposure in cows. Feeding deoxynivalenol-contaminated diets for 5 d did not alter feed intake or milk production nor were the milk concentrations of calcium, phosphorus, sodium, potassium, magnesium, or nitrogen altered.

FOOTNOTES

1 Animal Research Centre, Agriculture Canada, Ottawa, Ontario, on assignment for a Ph.D. program in the Department of Veterinary Biosciences.

2 Department of Food Science, Kagawa University, Kagawa, Japan.






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Copyright © 1986 by the American Dairy Science Association ®.