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Aspects of the Regulation of Long-Chain Fatty Acid Oxidation in Bovine Liver¹

Department of Animal Science, Michigan State University, East Lansing 48824

ABSTRACT

Factors involved in regulation of bovine hepatic fatty acid oxidation were examined using liver slices. Fatty acid oxidation was measured as the conversion of 1-[¹⁴C]palmitate to ¹⁴CO₂ and total [¹⁴C] acid-soluble metabolites. Extended (5 to 7 d) fasting of Holstein cows had relatively little effect on palmitate oxidation to acid-soluble metabolites by liver slices, although oxidation to CO₂ was decreased. Feeding a restricted roughage, high concentrate ration to lactating cows resulted in inhibition of palmitate oxidation. Insulin, glucose, and acetate inhibited palmitate oxidation by bovine liver slices. We suggest the regulation of bovine hepatic fatty acid oxidation may be less dependent on hormonally induced alterations in enzyme activity as observed in rat liver and more dependent upon action of rumen fermentation products or their metabolites on enzyme systems involved in fatty acid oxidation.

¹ Published with approval of the Director of the Agricultural Experiment Station as Journal Article Number 11790.

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