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Journal of Dairy Science Vol. 69 No. 8 2214-2218
© 1986 by American Dairy Science Association ®
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Determining Animal Drug Combinations Based on Efficacy and Safety

D. Dal Kratzer

The Upjohn Company, 7000 Portage Road, Kalamazoo, MI 49001

Shu Geng

Department of Agronomy and Range Science, University of California, Davis 95161

ABSTRACT

A procedure for deriving drug combinations for animal health is used to derive an optimal combination of 200 mg of novobiocin and 650,000 IU of penicillin for nonlactating cow mastitis treatment.

The procedure starts with an estimated second order polynomial response surface equation. That surface is translated into a probability surface with contours called isoprobs. The isoprobs show drug amounts that have equal probability to produce maximal efficacy. Safety factors are incorporated into the probability surface via a noncentrality parameter that causes the isoprobs to expand as safety decreases, resulting in lower amounts of drug being used.






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Copyright © 1986 by the American Dairy Science Association ®.