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Journal of Dairy Science Vol. 67 No. 10 2255-2264
© 1984 by American Dairy Science Association ®
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Glucose Kinetics, Plasma Metabolites, and Endocrine Responses during Experimental Ketosis in Steers1

R. R. Lyle2, G. deBoer, S. E. Mills3, R. W. Russel4, D. C. Beitz and J. W. Young

Nutritional Physiology Group, Department of Animal Science, Iowa State University, Ames 50011

ABSTRACT

Phlorizin and 1,3-butanediol were used to determine effects of glucosuria and ketonemia on concentrations of metabolites in blood plasma and on kinetics of glucose metabolism. Four steers received four treatments (control; control plus dietary 1,3-butanediol; control plus phlorizin injections; and control plus phlorizin and 1,3-butanediol) in a Latin square design. Treatments lasted 14 days. All steers received a 30% grain, 70% forage ration in equal meals every 2 h. Metabolite concentrations in blood plasma and urine and glucose kinetics were measured on each of the last 3 days of each treatment period. Phlorizin caused glucosuria; decreased plasma glucose, glucose total entry rate, and glucose recycling; and increased plasma free fatty acids and glucose irreversible loss. Glucose pool size was increased by 1,3-butanediol. Phlorizin plus 1,3-butanediol caused glucosuria and ketonuria; decreased plasma glucose; and increased blood ketone bodies, plasma free fatty acids, glucose irreversible loss, and glucose pool size. Growth hormone, insulin, and glucagon were not affected by treatment. Physiological perturbations in these steers were characteristic of some of those in ketotic cows.

FOOTNOTES

1 Journal Paper No. J-10977 of the Iowa Agriculture and Home Economics Experiment Station, Ames. Projects No. 2350 and 2389. This material is based upon work supported by the US Department of Agriculture under Agreement No. SEA-CR 901-15-160.

2 Ralston Purina Company, Beef and Sheep Research —2AP, Checkerboard Square, St. Louis, MO 63164.

3 Department of Animal Sciences, Purdue University, West Lafayette, IN 47907.

4 Department of Animal and and Dairy Sciences, Auburn University, Auburn, AL 36849.






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Copyright © 1984 by the American Dairy Science Association ®.