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Estimation of Free Myo-inositol in Milks of Various Species and Its Source in Milk of Rats (Rattus norvegicus)¹

Department of Biochemistry, College of Biological Sciences, University of Minnesota, St. Paul 55108

ABSTRACT

Free myo-inositol content of milk of rats and other rodents fed standard laboratory chow is 80 mg/100 g as compared to about 4 mg/100 g for cow milk. Feeding experiments with graded amounts of myo-inositol demonstrated that the myo-inositol content of milk is strongly influenced by dietary intake. Radioactivity from either [carbon—14] glucose or [hydrogen—3] myo-inositol injected intraperitoneally was incorporated rapidly into milk myo-inositol. Thus, both mammary biosynthesis and active transport contribute to the high myo-inositol in rat milk, but the latter is quantitatively the more important.

¹ Paper No. 9637 Scientific Journal Series, Minnesota Agricultural Experiment Station. Data taken from Ph.D. thesis of Si Myung Byun, University of Minnesota.

² Korean Advanced Institute of Science, Seoul, Korea.