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Effect of ß-Naphthoflavone on Calf Liver Metabolism of Aflatoxin B₁¹

Clemson University, Clemson, SC 29631

ABSTRACT

Eight male Holstein calves were raised to 6 wk of age on whole milk at 8% of body weight and calf starter ration (15% crude protein) free choice. For each of 2 days prior to sacrifice, four of the calves were selected at random and administered the mixed function oxidase inducer ß-napththoflavone by bolus in starch carrier at .005% of metabolic body weight. After sacrifice, 10,000 x g postmitochondrial supernatant preparations were made from the excised livers and incubated with a 50-µg challenge of aflatoxin B₁. Although there was no significant difference in total percent of the challenge metabolized, there was a large increase in aflatoxin M₁ production by liver preparations from calves administered the flavone inducer.

If the flavone family of inducers could alter the metabolic profile for aflatoxin in the adult lactating bovine, aflatoxin M₁ excretion rates could be increased and pathways for production of mutagenic metabolites could be enhanced.

¹ Technical Contribution No. 1933 of the South Carolina Agricultural Experiment Station, Clemson University.