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Elevated Cyclic Adenosine 3', 5' Monophosphate Enhances Lactic Acid Production by Streptococcus lactis

Department of Botany and Bacteriology, University of Arkansas, Fayetteville 72701

² Author to whom reprint requests should be addressed.

ABSTRACT

Elevation of cyclic adenosine 3', 5' monophosphate levels induced by prostaglandin E₁ enhanced growth of Streptococcus lactis C2 in a medium supplemented with lactose. The prostaglandin E₁-induced enhancement of growth did not appear to result from stimulation of the phosphoenolpyruvate phosphotransferase system because 0-nitrophenol-ß-D-galactopyranoside phosphorylation was not elevated by prostaglandin E_1, treatment. Measurement of the extracellular proteolytic activity revealed increased activity in prostaglandin E₁-treated cultures suggesting that an increase in the organic nitrogen source contributed to increased growth rate. Moreover, elevations in intracellular cyclic adenosine 3', 5' monophosphate induced by prostaglandin E₁ treatment increased lactic acid production at the cellular level.

¹ The Yalem Research Laboratories of The Jewish Hospital of St. Louis, Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110.