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Potential Use of 1,25-Dihydroxycholecalciferol for Prevention of Parturient Paresis¹

Departments of Dairy Science and Biochemistry, University of Wisconsin, Madison 53706

ABSTRACT

Twelve cows, at least third parity, were assigned randomly to either a control or treatment group. Treated cows received .4 mg of the vitamin D metabolite, 1,25-dihydroxycholecalciferol intra-musculary in 5 ml corn oil. Intramuscular injections were started 5 days before predicted calving with reinjections every 5 days until calving. Incidence of parturient paresis was 0 and 33% (2 of 6) in the treated and control groups. Response to treatment was rapid with elevated calcium in serum approximately 12 h postinjection. Treatment maintained or elevated calcium and phosphorus concentrations in serum during the critical period, 24 h pre- to 48 h postpartum, when milk fever is most likely to occur. There was, however, no significant difference between treatments at 72 h postpartum. Based on these observations 1,25-dihydroxycholecalciferol holds promise as a preventative of parturient paresis; however, further studies are needed on application and safety.

¹ Research supported by the College of Agricultural and Life Sciences, University of Wisconsin, Madison; Hatch Project 5051; and Industrial Gifts.

² Midland Cooperative, Inc., 2021 E. Hennepin Ave., Minneapolis, MN 55413.

³ National Animal Disease Center, USDA, SEA, P.O. Box 70, Ames, IA 50010.