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Vitamin B₁₂ Binding Proteins in Bovine Serum¹

Department of Animal Science, Cornell University, Ithaca, NY 14853

² Address reprint requests to this author.

ABSTRACT

Examination of bovine serum by the diethylaminoethyl cellulose small column method revealed three proteins binding vitamin B₁₂. The elution pattern suggested that they are similar to the three transcobalamins recognized in human serum. Distribution of unbound binding capacity among serum binders was assessed in serum from normal, ketotic, and B₁₂- and Factor B-supplemented cows in early lactation. No major differences were observed among groups; however, cow serum displayed a pattern different from human serum. Mean total binding capacity of bovine serum for B₁₂ as well as mean unbound binding capacity were lower than the corresponding means for human serum.

¹ Supported in part by a grant from Agway, Inc.