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Oral Nicotinic Acid as a Treatment for Ketosis¹

Department of Dairy Science, University of Wisconsin, Madison 53706

ABSTRACT

Changes in blood metabolites and milk production were measured in eight cows with subclinical or clinical ketosis following treatment with daily doses of 12 g nicotinic acid fed with the concentrate mixture. Ketotic cows displayed a positive milk ketone test, reduced milk production and feed intake, hypoglycemia, hyper-ketonemia, and elevated free fatty acids in plasma. The milk ketone test was negative in all cows 5 to 9 days following initiation of treatment. After 7 days of treatment, milk production and glucose in plasma were increased while there were decreases in plasma ß-hydroxybutyrate and free fatty acids. No relapses occurred.

¹ Research supported by the College of Agricultural and Life Sciences, University of Wisconsin, Madison.

² Agway Farm Research Center, RD 2, Tully, NY 13159.

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