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Journal of Dairy Science Vol. 61 No. 2 197-205
© 1978 by American Dairy Science Association ®
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Changes in Blood and Urine Composition from Feeding Polybrominated Biphenyls to Pregnant Holstein Heifers1

H. I. Durst, L. B. Willett, C. J. Brumm and F. L. Schanbacher

Department of Dairy Science, Ohio Agricultural Research and Development Center, Wooster 44691

ABSTRACT

The toxicity of a commercial preparation of polybrominated biphenyl was determined in 24 pregnant Holstein heifers that were allotted randomly to one of four experimental groups given 0 (I), .25 (II), 250 (III), and 25,000 (IV) mg per day of fireMaster BP-6 for 60 days or until the animals became moribund. Clin-icopathologic determinations were on day —1 prior to dosing, days 15, 30 and 60 during dosing, and following dosing on days 80, 110, 150, and 190 from start of dosing. In addition, samples were collected from moribund heifers of Group IV immediately prior to necropsy. Toxicity was not evident in heifers in Groups I, II, or III. Toxicity was induced in heifers in Group IV. Glutamic-oxaloacetic transaminase of serum was increased and calcium decreased as early as day 15 whereas significant increases in lactate dehydrogenase, urea nitrogen, and bilirubin, and decreases in albumin were not observed intil day 30 in heifers of Group IV. Analysis of urine from moribund heifers of Group IV revealed moderate proteinuria and decreased specific gravity. Evaluation of clinicopathologic data has suggested that the polybrominated biphenyls fed were renal toxins with no clear evidence of hepatotoxicity.

FOOTNOTES

1 Approved as Journal Article No. 100-77, Ohio Agricultural Research and Development Center, Wooster 44691.






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Copyright © 1978 by the American Dairy Science Association ®.