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Journal of Dairy Science Vol. 59 No. 6 1016-1018
© 1976 by American Dairy Science Association ®
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Amino Terminal Sequence and Location of Phosphate Groups of the Major Human Casein

Rae Greenberg,, Merton L. Groves and Robertson F. Peterson

Eastern Regional Research Center1, Philadelphia, PA 19118

ABSTRACT

The amino acid sequence of the first 28 residues of the major human casein was determined. This protein in multi-phosphorylated forms (0 to 5 phosphorous per molecule) was compared to cow beta-casein which is similar in composition but phosphorylated at a constant level. After sequencing the phosphate-free human casein, phosphorylated seryl and threonyl residues were located in three of the other phosphorylated forms by examining the aqueous layer of the phenylthio-hydantoin conversion step during automatic liquid phase sequencing. Phosphate groups on specific seryl/threonyl residues suggest a biosynthetic mechanism involving stepwise phosphorylation or dephosphorylation.

FOOTNOTES

1 Agricultural Research Service, US Department of Agriculture.






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Copyright © 1976 by the American Dairy Science Association ®.