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Lactoferrin Concentration During Involution of the Bovine Mammary Gland^{1 ,2,}

Department of Dairy Science, Ohio Agricultural Research and Development Center, Wooster 44691

ABSTRACT

Electroimmunodiffusion assay was used to quantitate changes in lactoferrin concentration in mammary secretions during involution of the bovine mammary gland. Concentration of lactoferrin began to increase 2 to 4 days after cessation of regular milking and continued to increase linearly at a rate of 1.15 mg/ml per day as a result of increased net synthesis of lactoferrin during the first 14 to 21 days of involution. Maximum lactoferrin concentration (approximately 20 mg/ml) was attained after 3 to 4 wk of involution. These changes represent a 100-fold increase in lactoferrin concentration over that in normal milk. Maximum lactoferrin concentration was variable between cows. In some cows, the concentration of lactoferrin plateaued at less than 10 mg/ml after 10 days of involution. In others, much higher lactoferrin concentrations of 75 to 100 mg/ml were measured. Lactoferrin concentration decreased markedly prior to parturition and onset of lactation. The increase in lactoferrin concentration during mammary gland involution appeared to be related closely to the process of involution.

¹ Journal Article 42-75, Ohio Agricultural Research and Development Center, Wooster 44691.

² A preliminary report was presented at the 5th Central Meeting of the American Chemical Society, Cleveland, OH 1973. Abstr. B16.

³ Data in this paper were presented to the Graduate Faculty of The Ohio State University in partial fulfillment of the requirements for the degree of Master of Science, 1972. Present address: Department of Biochemistry, Case Western Reserve University, Cleveland, OH.

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