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Absorption, Excretion, and Tissue Deposition of Titanium in Sheep¹

Comparative Animal Research Laboratory, Oak Ridge, TN 37830

ABSTRACT

Titanium metabolism was measured in three 18 kg lambs each fed 450 g chopped hay daily. Two of the lambs were dosed orally and one intravenously with 3 µCi titanium-44 each. Clearance of the intravenous dose was extremely slow; after oral administration, however, no titanium-44 was detected in blood plasma for 48 h. Over 96% of the oral dose was recovered in feces and digestive tract contents. Titanium-44 absorption, estimated from total carcass recovery and by comparison of concentrations in internal organs of orally and intravenously dosed lambs, was less than .5%. Fecal titanium could be a satisfactory index of soil ingestion by grazing ruminants.

¹ Research supported by the US Department of Agriculture and University of Tennessee Agricultural Experiment Station.

² Syntex Agri Business, Inc., Springfield, MO 65805.