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Effect of Adrenalectomy and Insulin Insufficiency Upon the Adenosine 3', 5' Cyclic Monophosphate System of the Rat Mammary Glands¹

Department of Animal Science, University of California, Davis 95616

ABSTRACT

Effects of adrenalectomy and acute insulin insufficiency upon tissue adenosine 3', 5' cyclic monophosphate concentrations, and adenyl cyclase, phosphodiesterase, and protein kinase activities were investigated. Adrenalectomy decreased intracellular adenosine 3', 5' cyclic monophosphate 53% and increased the activities of both adenyl cyclase and phosphodiesterase. Cortisol therapy returned these to normal. During insulin insufficiency caused by anti-insulin serum, mammary adenosine 3', 5' cyclic monophosphate concentrations increased. The acute effects of insulin insufficiency and chronic effects of adrenalectomy suggest that insulin acts upon rat mammary glands to decrease and glucocorticoids, acting over longer term, to increase adenosine 3', 5' cyclic monophosphate concentrations.

¹ Supported in part by USPHS-NIH Grant AM-07672. Taken from Ph.D. Thesis of S. L. Louis.