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Feeding and Drinking in Sheep Following Hyphothalamic Injections of Carbachol

Smith Kline Animal Health Products, 1600 Paoli Pike, West Chester, PA 19380
University of Pennsylvania, Philadelphia, Pennsylvania 19104

ABSTRACT

Carbachol (carbamycholine chloride) (28 nmol) was injected on 77 occasions into 69 loci in the hypothalamus of 13 sheep. Of the injections, 31% elicited feeding, 14% elicited drinking, and 4% elicited both feeding and drinking responses. One carbachol feeding locus in each of eight sheep was injected with carbachol at doses from 1.75 to 112 nmol. Feeding was elicited by 3.5 nmol or more carbachol. At carbachol-bound feeding loci in eight sheep, the effect of carbachol was blocked by atropine, a cholinergic antagonist, but not by phe-noxybenzamine or LB-46, a and ß-adrenoceptor antagonists, respectively; atropine alone had no effect. Increases in water intake accompanying carbachol-induced feeding may be due to increased dry matter intake. There were no significant effects on intraperitoneal temperature. Cholinergic pathways passing through the hypothalamus of sheep is proposed as an explanation for the feeding.

¹ On leave of absence from the Department of Animal Physiology and Nutrition, University of Leeds, Leeds, United Kingdom.