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Journal of Dairy Science Vol. 57 No. 6 677-682
© 1974 by American Dairy Science Association ®
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25-Hydroxycholecalciferol (25-OH-D3). III. Effect of Dosage on Soft Tissue Integrity and Vitamin D Activity of Tissue and Milk from Dairy Cows1

W. G. Olson, N. A. Jorgensen, A. N. Bringe, L. H. Schultz and H. F. Deluca

Departments of Dairy Science and Biochemistry, University of Wisconsin, Madison 53706

ABSTRACT

In Trial I, eight cows, two per treatment, were given the following doses of 25-hydroxycholecalciferol: (1) 1.0 mg orally daily for 14 days, (2) 4.0 mg, (3) 8.0 mg, or (4) 16.0 mg intramuscularly in 5 ml sesame oil. No clinical or pathologic evidence of hypervitarninosis D was found. Tissue from animals slaughtered 14 to 35 days after treatment revealed no evidence of tissue irritation and less than a twofold increase in vitamin D content. Tissue from control animals contained 18 to 26 IU of vitamin D per 100 g compared to 20 to 48 IU per 100 g from treated animals.

In Trial II, the mean vitamin D content of milk taken on Day 4 postpartum from seven orally-treated cows was not greatly different than that of seven control cows, 35 compared to 31 IU per liter. Similar values for seven intramuscularly injected cows were 75 IU vitamin D per liter compared to 38 for five control cows. Thus, short-term administration of 25-hydroxycholecalciferol at dosages that effectively reduce the incidence of parturient paresis appear safe for the animal, and the products produced by these animals safe for human consumption.

FOOTNOTES

1 Research supported by the College of Agricultural and Life Sciences, University of Wisconsin, Madison, and Hatch Project 1661.






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Copyright © 1974 by the American Dairy Science Association ®.