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Journal of Dairy Science Vol. 57 No. 11 1410-1413
© 1974 by American Dairy Science Association ®
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Nucleotide Inhibition of Post-Orotate Pyrimidine Synthesis Pathway Enzymes of Bovine Mammary Tissue

J. L. Robinson and B. L. Larson

Department of Dairy Science, University of Illinois, Urbana 61801

ABSTRACT

Effects of various nucleotides are evaluated on enzymes of the post-orotate portion of the pyrimidine synthesis pathway from lactating bovine mammary tissue. Orotate phosphoribosyltransferase shows minimal activation by most nucleotides tested, but orotidine-5'-phosphate decarboxylase is highly inhibited by several nucleotides with xanthosine, cytidine, and uridine 5'-phosphates being the most effective. It is possible that product inhibition by uridine Diphosphate of orotidine 5'-phosphate decarboxylase is an important factor in the accumulation of orotate in bovine milk.






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Copyright © 1974 by the American Dairy Science Association ®.