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Diminished Hypercalcemic Response to Parathyroid Extract in Prepartum Cows¹

Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, New Bolton Center, Kennett Square 19348

ABSTRACT

Parathyroid extract was administered to five cows shortly before and after parturition in addition to postpartal injections only in two other cows. Plasma calcium concentration was measured in each experiment before and after administration of the extract. The postpartal response to parathyroid extract, as assessed by elevation of plasma calcium concentration, occurred more consistently and appeared to be greater than that observed before parturition. The possible mechanisms responsible for diminished prepartal responsiveness and its potential significance in relation to parturient paresis are discussed.

¹ This work supported in part by USPHS grant no. AM-16,983.

² Visiting instructor in Medicine supported by a grant of the Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung. Present address: Klinik für Nutztier-und Innere Pferdekrankheiten, Universität Bern, Bremgartenstr. 109a, 3000 Berne, Switzerland.

³ Recipient of USPHS Research Career Development Award No. 1-K3-AM-14,874. Present address: Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater 74074.

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