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Journal of Dairy Science Vol. 56 No. 7 889-895
© 1973 by American Dairy Science Association ®
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25-Hydroxycholecalciferol (25-OHD3) II. Efficacy of Parenteral Administration in Prevention of Parturient Paresis1

W. G. Olson, N. A. Jorgensen, L. H. Schultz and H. F. Deluca

Departments of Dairy Science and Biochemistry, University of Wisconsin, Madison 53706

ABSTRACT

Three trials involving subcutaneous or intramuscular injection of 25-hydroxycholecalciferol in 5 ml of sesame oil tested its efficacy in preventing parturient paresis. Subcutaneous injection of 2.0 mg of 25-hydroxycholecalciferol (Trial I) was unsatisfactory because of unpredictable absorption rate of the oil and poor protection. Intramuscular injection of 4.0 or 8.0 mg 25-hydroxycholecalciferol prevented parturient paresis when calving occurred between 72 h and 10 days after injection. When all treated cows were compared, administration of 4.0 mg 25-hydroxycholecalciferol (Trial II) reduced the overall incidence from 29% in control cows (7 of 24) to 16% in treated cows (4 of 21) while administration of 8.0 mg 25-hydroxycholecalciferol (Trial III) reduced the incidence from 52% in control cows (12 of 23) to 19% in treated cows (4 of 21). No clinical signs of hypervitaminosis D were observed in any treated animals.

FOOTNOTES

1 Research supported by the College of Agricultural and Life Sciences, University of Wisconsin, Madison, and by Hatch Project 1661.




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M. S. Taylor, K. F. Knowlton, M. L. McGilliard, W. M. Seymour, and J. H. Herbein
Blood Mineral, Hormone, and Osteocalcin Responses of Multiparous Jersey Cows to an Oral Dose of 25-Hydroxyvitamin D3 or Vitamin D3 Before Parturition
J Dairy Sci, June 1, 2008; 91(6): 2408 - 2416.
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