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Reduction of Iodine Transfer to Milk of Cows after Perchlorate Ingestion¹

Department of Physical Biology, Cornell University, Ithaca, New York 14850

ABSTRACT

These experiments quantitate the relation between amount of perchlorate ingested and radioiodine transferred to milk of the cow when radioiodine is fed daily or after radioiodine administration ceases.

When radioiodine was given daily, graded doses of perchlorate, from 10 to 4,000 mg/day, increased plasma iodine in accord with Y = 88.1 ^X.052 (Y = % of control value and X is the daily dose of perchlorate in milligrams.) Curves for iodine-125 in milk and ratio of milk to plasma iodine-125 between the limits of 50 and 1,000 mg perchlorate daily were fitted by Y = 794.8 ^X-.525 and Y = 1,046.5^X-.601; these same curves between 10 and 50 mg perchlorate daily were fitted by Y = 85.6 + .37 X and Y = 82.3 + .28 X. Between 1,000 and 4,000 mg perchlorate, these curves had a slope of 0. These data indicate that perchlorate can inhibit the iodide-transfer mechanism of the mammary gland of the cow and that a ratio of milk to iodine of .2 indicates complete blockage of this transfer.

Administration of 1 g of perchlorate daily leads to 55% less radioiodine being transferred to milk after administration of iodine 125 has ceased.

¹ Supported in part by U.S.A.E.C. Contract at (II-I)-3167.

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