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1 University of Pennsylvania, School of Veterinary Medicine, Department of Clinical Sciences, Kennett Square 19348
and the 2 Massachusetts Institute of Technology, Department of Nutrition and Food Science, Cambridge 02139
ABSTRACT
Plasma insulin and glucose concentrations were higher prepartum (2 to 21 days) than postpartum in Jersey cows. Highest prepartum concentrations were in cows that later developed hypocalcemia. Hypocalcemic cows showed low plasma insulin concentrations and high plasma glucose concentrations. Plasma insulin increased and plasma glucose decreased after calcium borogluconate infusion in hypocalcemic but not in normal animals. These results further define the altered hormonal state of parturient dairy cows and support previous in vivo and in vitro observations that physiologic concentrations of calcium are required for glucose stimulation of insulin secretion.
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