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Vitamin E Supplementation During Acute Hypovitaminosis A of the Calf¹

Nutritional Sciences and Pathobiology Departments, University of Connecticut, Storrs 06268

ABSTRACT

To study whether tocopherol supplementation would alleviate pathological lesions occurring in vitamin A deficiency, d,l-alpha-tocopheryl acetate was added to a group of six or withheld from a group of seven vitamin A deficient calves for 4 weeks. Plasma vitamin A, hematocrit, plasma and whole blood potassium, serum total protein and protein distribution, serum glutamic-oxalacetic and glutamic-pyruvic transaminase activities, and cerebrospinal fluid pressures were not significantly affected by vitamin E supplementation. Plasma tocopherol concentrations were markedly increased, and red blood cell hemolysis induced by hydrogen peroxide was decreased. Sodium and potassium content of the heart averaged essentially the same for both groups. Incidences of squamous metaplasia of the parotid gland and duct, papilledema, necrosis of the optic nerve, and pituitary cysts were not significantly different.

¹ Scientific Contribution 524, Storrs Agricultural Experiment Station, University of Connecticut, Storrs. This research was supported in part by a Public Health Service Research Grant NR-02108 from the National Institute of Neurological Diseases and Stroke, a National Institutes of Health Training Grant GM 1199 (KCH and RJC), and grant-in-aid funds from Hoffmann - La Roche, Nutley, New Jersey.

² Present address: Nutrition Department, Harvard School of Public Health, Boston, Massachusetts 02115.

³ Present address: Animal Sciences Department, Rutgers University, New Brunswick, New Jersey 08903.

⁴ Present address: Oral Biology Department, School of Dental Medicine, University of Connecticut, Storrs 06268.