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Pesticide Residues in Milk and in Tissues Following Long, Low 2, 2-bis(p-chlorophenyl)-1, 1, 1-trichloroethane Intake^1,2,

Department of Dairy and Food Sciences, The University of Arizona, Tucson 85721

ABSTRACT

Unbred heifers in three groups of four animals were fed one of three 2, 2-bis(p-chloropheny1)-1, 1, 1-trichloroethane intakes: 250, 500, or 1,000 ppb (parts per billion) of the total feed consumed. The animals were maintained on these intakes until ends of their first lactations when one animal in each group was sacrificed for tissue sampling and analysis. The nine remaining animals were then placed on a relatively pesticide-free diet during their second lactation. In lactation 1, as dosage decreased, the ratio of feed dose to milk fat pesticide residue increased. A 1,000 ppb feed gave a ratio of 1:2.2, 500 ppb resulted in 1:2.5, and 250 ppb yielded 1:3.5. In the second lactation, the biological half-life for the group receiving 250 ppb of pesticide (7.3 mo) was greater than that for the groups receiving 500 ppb (3.9 mo) or 1,006 ppb (4.4 mo).

Renal and udder adipose tissues and total udder tissue had the most pesticide at each dosage with 2,2-bis(p-chlorophenyl)-1, 1-dichloroethane being the major metabolite.

Despite the relatively low blood 2, 2-bis(p-chlorophenyl)-1, 1-dichloroethane, this metabolite could indicate previous 2, 2-bis(p-chlorophenyl)-1, 1, 1-trichloroethane exposure.

¹ Journal paper 2060 d the Arizona Agriculture Experiment Station.

² Supported in part by a grant from the United Dairymen of Arizona, Tempe, Arizona.

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