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Permanently Installed Digestive Cannulae

Health Protection Branch, Tunney's Pasture, Ottawa, Ontario, Canada

ABSTRACT

Introduction

There are numerous reasons for research scientists expending the substantial effort required surgically to establish and maintain permanent digestive cannulae in experimental animals. The overall objectives are to obtain information concerning the function and response of the digestive system to different conditions. The ultimate aim in such experiments is to utilize the knowledge gained to increase production of the milking cow. Except in unique situations these data are applied to "normal" conscious animals. The confidence in interpretation of these data and in their extrapolation to applied situations will be greatly facilitated if the data are from subjects whose condition is as close to the physiological norm as possible. This requirement alone implies that acute experiments on whole animals or in vitro experiments on isolated animal tissues can present problems in the application of results to field conditions. For example, general anesthetics produce profound changes in such physiological parameters as blood flow, motility of the digestive tract, and activity of various endocrine and exocrine glands.