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Failure of DEAE Sephadex Feeding to Lower Blood and Milk Lipids of Cows

Animal Science Research Division, USDA, Beltsville, Maryland 20705

ABSTRACT

DEAE Sephadex, the diethylaminoethyl derivative of a cross-linked dextran, in some species has lowered serum sterols, phospholipids, and triglycerides by binding bile acids in the intestinal tract and increasing lipid excretion in feces. This research examines its effect in dairy cows. First, in in vitro incubation tests at 39 C, the compound was not degraded by rumen microorganisms. When fed to Holstein cows at 0, 1, 2, and 4%, Sephadex had no effect on blood or milk cholesterol and other lipids. These results contrast with those of others in simple-stomached animals in which serum lipids are lowered and fecal excretion of fats increased when Sephadex is fed. When a simulated cow diet was given to rats, the excretory fat augmentation by DEAE Sephadex was essentially abolished. This suggests that failure of cows to respond to DEAE Sephadex may derive from the nature of the ruminant diet.