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Nicotinic Acid Loading of Normal Cows: Effects on Blood Metabolites and Excretory Forms¹

Department of Dairy Science, University of Wisconsin, Madison 53706

ABSTRACT

Oral administration of 160 g nicotinic acid in 4 doses to normally fed, lactating cows resulted in declines followed by rebound elevations in plasma nonesterified fatty acids. Urine volume increased 8 to 16 hr after nicotinic acid administration. Urinary N'-methylnicotinamide and nicotinamide excretion accounted for only 6.5 g of the 160 g nicotinic acid given. The main excretory form during the 56-hr sampling was the unaltered nicotinic acid which accounted for 53.2 g of the administered dose.

¹ Research supported by the College of Agricultural and Life Sciences, University of Wisconsin, Madison, and by Grant AM 08546 from the National Institute of Arthritis and Metabolic Diseases.

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				J. A. A. Pires and R. R. Grummer The Use of Nicotinic Acid to Induce Sustained Low Plasma Nonesterified Fatty Acids in Feed-Restricted Holstein Cows J Dairy Sci, August 1, 2007; 90(8): 3725 - 3732. [Abstract] [Full Text] [PDF]