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Morphology of Experimental Respiratory Carcinogenesis

Proceedings of a Biology Division, Oak Ridge National Laboratory, Conference held in Gatlinburg, Tennessee, May 13–16, 1970. Sponsored by National Cancer Institute and U.S. Atomic Energy Commission. Editors: P. Nettesheim, M. G. Hanna, Jr., and J. W. Deatherage, Jr., Oak Ridge National Laboratory

College of Veterinary Medicine, University of Illinois, Urbana

ABSTRACT

"It is now recognized that a multiplicity of host and environmental factors are operative in the induction of pulmonary neoplasms. The primary purpose of this conference and the previous conference (Inhalation Carcinogenesis, held October 8–11, 1969) was to evaluate critically the adequacy of the available experimental models for studying the multifactorial etiology of lung cancer. The methodologies, experimental designs, and biological end points used in these studies are reviewed. The purpose of the first conference was to evaluate the importance and feasibility of inhalation techniques for studies in respiratory carcinogenesis. The present conference deals specifically with the morphological characteristics of tumors in the respiratory tract of common laboratory and domestic animals, and their induction by various carcinogens and methods of exposure.

"A prerequisite for the meaningful exploration of the causative factors and mechanisms leading to tumor induction in the respiratory tract is a thorough understanding of the structural and functional components of this complex organ system.