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Triton-Induced Hyperlipemia in Goats Under Various Physiological Conditions¹

University of Wisconsin, Madison 53706

ABSTRACT

Goats were given intravenous injections (.2 or .4 g per kilogram of body weight) of detergent Triton WR 1339 to measure triglyceride entry into the blood under fed, fasted, lactating, or phloridzinized and fasted conditions. Blood triglycerides increased up to 160-fold 72 hours after injection. Total cholesterol and phospholipids also increased 5 to 9-fold while free fatty acids, acetone, ketone bodies, and blood glucose were not affected by Triton injection. Fed or fasted nonlactating goats had a triglyceride entry of from .14 to .22 mg per minute per kilogram body weight. Triton was not effective in blocking triglyceride exit from the blood in fed lactating animals even though triglyceride in the plasma increased 12 to 15-fold. Milk production and milk fat composition were not changed even at the highest circulating lipid concentration. Triton had no apparent effect on the health of the goats as they ate and behaved normally.

¹ Supported in part by Grant AM 80546-06 from the National Institute of Arthritis and Metabolic Diseases, Bethesda, Maryland.

² Present address: Miracle Feeds Division, Ogilvie Flour Mills Co. Ltd., Montreal, Quebec, Canada.