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Hypoglycemia in Ketotic Cows

Section of Nutrition, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Kennett Square 19348

ABSTRACT

Two types of hypoglycemia have been differentiated in ketotic cows by tracer parkinetics. One is associated with fasting kebetosis and is characterized by decreases in the mass of glucose in rapid exchange with plasma glucose and in the rate of glucose transport through this pool. The other occurs in cows with spontaneous ketosis and is characterized by undiminished glucose transport or mass and by changes in glucose distribution. Similar changes follow insulin administration and opposite changes follow glucocorticoid administration. These differences in glucose kinetics between fasting ketosis and spontaneous ketosis are complemented by a dozen other demonstrated differences between the two conditions, mainly concerning ruminal, hepatic and mammary metabolism. These metabolic differences suggest the desirability of distinguishing between different types of ketosis for designing and testing control measures.