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Metabolism of ¹⁴C-carbonyl Labeled Supracide by Lactating Cows

Department of Dairy Science, Virginia Polytechnic Institute and State University, Blacksburg 24061

ABSTRACT

The metabolism of a new organophosphorus insectide, Supracide, intended for controlling alfalfa weevil and other insects was studied in lactating cows. The labeled compound was rapidly metabolized and eliminated from the bovine. The major routes of carbon-14 excretion were urinary and respiratory. One to two per cent of the label appeared in milk, but no parent compound was present. A small percentage of milk radioactivity was identified as a sulfoxide and sulfone metabolite. The principal radioactivity found in milk was retained in the nonextractable fraction. This was probably due to incorporation of ¹⁴C-metabolites into synthesized natural nonfat solids of milk.