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Effect of Microsomal Enzyne Inducing Drugs on DDT and Dieldrin Elimination from Cows

Animal Science Research Division, ARS, USDA, Beltsville, Maryland 20705

ABSTRACT

After being contaminated with pesticides, the cows were fed uncontaminated diets for at least 14 days and then treated with various drugs in attempts to accelerate the elimination of pesticides stored in body tissues. In Experiment 1, cows were fed 5 g per day pentobarbital for 14 days. The first-order rates of decline of dieldrin, DDD, and DDT concentrations in milk fat were 0.030, 0.059, and 0.022 day^–1 for control and 0.044, 0.120, and 0.026 day^–1 for treated. In Experiment 2, cows received 3 g pentobarbital intravenously followed by 5 g per day orally for 20 days and 24 g per day for the next 20 days. Decline rates for dieldrin, DDE, and DDT, were 0.026, 0.010, and 0.019 day^–1 for control and 0.027, 0.011, and 0.019 day^–1 for treated. In Experiment 3, the treated groups were fed either 5 g per day phenobarbital or diphenylhydantoin. Decline rates for dieldrin and DDE were 0.018 and 0.016 day^–1 for control, 0.035 and 0.021 day^–1 for phenobarbital, and 0.018 and 0.014 day^–1 for diphenylhydantoin. The responses of DDD to pentobarbital, dieldrin to phenobarbital, and DDE to phenobarbital were significant. Peed consumption, milk yield, and fat tests were not affected by the drugs.