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Journal of Dairy Science Vol. 54 No. 3 360-363
© 1971 by American Dairy Science Association ®
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Acute Effect of 9{alpha}-Fluoroprednisolone Acetate1 (9{alpha} FFA) on Blood Leukocytes and Somatic Cell Content of Milk

E. M. Convey, L. S. Miller and H. A. Tucker

Department of Dairy, Michigan State University, East Lansing 48823

ABSTRACT

Lactating Holstein cows received 0 (saline), 5, or 10 mg 9{alpha} FFA immediately following morning milking. Thereafter blood samples were collected hourly until completion of the evening milking 10 hours later. Treatment with 9{alpha} FFA resulted in a linear increase in plasma glucose during post-treatment (P < 0.05). Total leukocytes in blood increased linearly (P < 0.05) with time following 5 or 10 mg 9{alpha} FFA but not after saline. This increase could be attributed primarily to an increase in blood neutrophils. Treatment with 9{alpha} FFA decreased (P < 0.05) blood eosinophils but it did not alter numbers of lymphocytes or monocytes. Both 5 and 10 mg 9{alpha} FFA reduced milk yield at 10 and 24 hours post-treatment (P < 0.01) but differences attributed to dose were not significant (P > 0.10). Direct microscopic measurements of somatic cell content of fore, primary and residual milk revealed no significant (P > 0.10) effect of 9{alpha} FFA on number of total somatic cells, granulocytes, agranulocytes, or epithelial cells. These results suggest that corticoid-induced leukocytosis of blood is not reflected by increased somatic cell numbers in milk.

FOOTNOTES

1 The Upjohn trademark for 9{alpha}-fluoroprednisolone acetate is Predef.

Journal Article 5229 from the Michigan Agricultural Experiment Station.






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Copyright © 1971 by the American Dairy Science Association ®.