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Department of Dairy Science, Ohio Agricultural Research and Development Center, Wooster 44691
ABSTRACT
A combination of estrogen and progesterone administered for 7 days to non-lactating, nonpregnant cows caused the mammary gland to fill with a fluid similar in composition to normal bovine colostrum. The movement of serum protein into lacteal secretion appeared to be selective for IgG1 when compared to either IgG2 or blood serum albumin. The mean quantity of IgG1 removed from the glands of four animals on a 4 x 4 Latin square design was 79.1 g following estrogen-progesterone treatment as compared to 14.0 g following control treatment. The maximum amount of IgG1 removed was 129.3 g following estrogen-progesterone treatment.A combination of estrogen and progesterone administered for 7 days to non-lactating, nonpregnant cows caused the mammary gland to fill with a fluid similar in composition to normal bovine colostrum. The movement of serum protein into lacteal secretion appeared to be selective for IgG1 when compared to either IgG2 or blood serum albumin. The mean quantity of IgG1 removed from the glands of four animals on a 4 x 4 Latin square design was 79.1 g following estrogen-progesterone treatment as compared to 14.0 g following control treatment. The maximum amount of IgG1 removed was 129.3 g following estrogen-progesterone treatment.A combination of estrogen and progesterone administered for 7 days to non-lactating, nonpregnant cows caused the mammary gland to fill with a fluid similar in composition to normal bovine colostrum. The movement of serum protein into lacteal secretion appeared to be selective for IgG1 when compared to either IgG2 or blood serum albumin. The mean quantity of IgG1 removed from the glands of four animals on a 4 x 4 Latin square design was 79.1 g following estrogen-progesterone treatment as compared to 14.0 g following control treatment. The maximum amount of IgG1 removed was 129.3 g following estrogen-progesterone treatment.
Treatment with estrogen alone resulted in apparent colostrum formation in one of the four animals while progesterone given without estrogen never formed colostrum. The results suggest that changing estrogen and progesterone the last 4 to 6 weeks of pregnancy, either directly or indirectly, exert a controlling influence on the selective transport of IgG1 to bovine lacteal fluid and, thus, colostrum formation.
Hormone treatment also affected the concentration of lactoferrin in lacteal fluid but not the total quantity removed from the gland. Changes in lactoferrin for one cow are discussed in light of a possible connection between lactoferrin synthesis and involution of the gland. The suggestion is l^hat the iron-binding protein, lactoferrin, may be as important to defense of the mammary gland as immunoglobulin.
1 Approved as Journal Article 60-71, Ohio Agricultural Besearch and Development Center, Wooster 44691.
2 Present address: Merck Inc., Rahway, New Jersey.
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