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Effect of Perchlorate on the Milk-Plasma Radioiodine Ratio of Intact and Thyroidectomized Goats¹

Department of Physical Biology, New York State Veterinary College, Cornell University, Ithaca, New York 14850

ABSTRACT

The purpose of this study was to investigate the effects of graded doses of sodium perchlorate upon the iodide-concentrating mechanism of mammary gland of intact and thyroidectomized goats given twice-daily doses of 125 I over extended periods. Perchlorate was given intravenously at 0.25, 0.5, 1.0, 2.0, 4.0, and 8.0 mg/kg of body weight as a single dose or orally as twice-daily doses for extended periods. The regression equation of the milk/plasma radioiodine ratio on the single intravenous perchlorate dose was Y = 49.5 – 32.0 log X with no difference between intact and thyroidectomized goats. The mammary gland iodide-concentrating mechanism can operate independently of the thyroid. Plasma nonbound iodide was described by the equation Y = 32.3 + 61.2 log X for both classes of goats. When perchlorate was given in twice-daily oral doses for 7 days, the depression of the milk/plasma ratio at the end of this period was greater than after the single intravenous administration of perchlorate.

¹ Supported in part by AEC Contract AT-30-1 (4039).

² Visiting Fellow. Present address: Institute for the Application of Nuclear Energy in Agriculture, Veterinary Medicine and Forestry, Zemun, Baranjska, Yugoslavia.