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Journal of Dairy Science Vol. 53 No. 6 801-807
© 1970 by American Dairy Science Association ®
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Comparative Goldthioglucose Effects on Goats, Sheep, Dogs, Rats, and Mice1

Clifton A. Baile, Jean Mayer, B. R. Baumgardt and Arne Peterson

Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115
and Department of Animal Science, Pennsylvania State University, University Park 16802

ABSTRACT

Goldthioglucose injections produce lesions in the ventromedial area of the hypothalamus readily in mice and in some cases in rats. These lesions usually result in hyperphagia and obesity. Glucose and insulin solutions were injected into jugular veins of goats and sheep for an hour to increase glucose utilization rate which in mice increases the severity of the hypothalamic lesion. Immediately folowing this, goldthioglucose and insulin were injected into a carotid artery for 30 minutes while the opposite carotid was occluded. This treatment caused high levels of goldthioglucose in the brain. Even though the gold concentration of the venous blood was 30 to 40 times that of mice which developed hypothalamic lesions, the goats and sheep did not develop hypothalamic lesions. Dogs similarly treated or rats injected intravenously with goldthioglucose also did not have hypothalamic lesions. Mice injected intraperitoneally first with glucose and insulin for 1 hour and then goldthioglucose and insulin for 30 minutes had hypothalamic lesions. Sheep suffered some impairment of liver function and severe kidney dysfunction which was often lethal. The ruminants were sensitive to the toxic effects of goldthioglucose but resistant to any hypothalamic-lesioning effect.

FOOTNOTES

1 Approved for publication by the Pennsylvania Agricultural Research Station as Manuscript 3707.






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Copyright © 1970 by the American Dairy Science Association ®.